Retinal abnormalities in transgenic mice overexpressing aberrant human FUS[1-359] gene

Retinal damage is an optional sign in a number of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). The aim this work was to assess the structural and functional state retina murine model ALS caused by overexpression aberrant FUS protein [1-359]. retinal examination carried out on 12 transgenic 13 wild-type mice 2.5–3 months age. study revealed not statistically significant higher level ophthalmoscopic violations FUS[1-359] mice. Moreover, gene expression assay confirmed increased inflammatory genes Vegfa, Il1b, Il6, Icam1, Tnfa. However, despite detected abnormalities, western blot analysis quantitative PCR did detect mRNA products transgene